s pneumoniae strain cdc cs109  (ATCC)

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: In vivo PAE of daptomycin against S. pneumoniae ATCC 10813 after administration of single doses of 2.5 (triangles) and 10 (squares) mg/kg. T > MIC, time that the concentration remains above the MIC.

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques: In Vivo, Concentration Assay

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: In vivo PAEs of free and total daptomycin concentrations of against S. aureus and S. pneumoniae

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques: In Vivo

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: Static doses of daptomycin for different dosing intervals

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques:

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: Dose-response curves for daptomycin against various strains of S. pneumoniae.

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques:

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: MICs, static doses, and magnitudes of 24-h AUC/MIC and peak/MIC ratios required to produce a bacteriostatic effect and killing of 1 and 2 log 10 CFU per thigh over 24 h

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques:

Journal:

Article Title: In Vivo Pharmacodynamic Activity of Daptomycin

doi: 10.1128/AAC.48.1.63-68.2004

Figure Lengend Snippet: AUC over 24 h for free daptomycin associated with the static dose and doses producing killing of 1 and 2 log10 CFU/thigh for multiple strains of S. pneumoniae and S. aureus.

Article Snippet: The low values for E. faecium may reflect the poor growth of the two strains of E. faecium in control mice (0.34 and 0.37 log 10 CFU/thigh over 24 h). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 4. caption a7 Dose-response curves for daptomycin against various strains of S. pneumoniae . fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window FIG. 5. caption a7 Dose-response curves for daptomycin against various strains of S. aureus (circles) and E. faecium (squares). table ft1 table-wrap mode="anchored" t5 TABLE 3. caption a7 Organism MIC (mg/liter) Static dose (mg/kg/24 h) a 24-h AUC/MIC ratio Peak/MIC ratio Static dose 1 log killing 2 log killing Static dose 1 log killing 2 log killing S. pneumoniae ATCC 10813 0.12 2.16 168 390 582 25.1 48.2 86.5 S. pneumoniae CDC 145 0.12 0.954 74.7 108 157 11.8 16 23.4 S. pneumoniae CDC 1199 0.12 2.62 203 346 594 30.5 51.5 88.1 S. pneumoniae CDC 1396 0.12 1.5 117 150 190 17.4 22.3 28.3 S. pneumoniae CDC 673 0.12 3.05 237 467 815 35.5 69.5 121 S. pneumoniae CDC 1325 0.25 5.34 199 373 673 29.8 55.5 100 S. pneumoniae CDC 49619 0.25 4.9 182 337 703 27.3 50 104 S. pneumoniae CDC 1020 0.25 3.39 126 215 395 18.9 32 58.5 Mean ± SD (95% CI) for S. pneumoniae 160 ± 51 (72-316) 290 ± 121 (100-660) 498 ± 131 (117-813) 24 ± 7.6 (11-44) 42.1 ± 17.2 (15-98) 73.9 ± 34.2 (20-204) S. aureus ATCC 25923 0.5 20.8 388 594 896 59 109 197 S. aureus ATCC 33591 0.5 28.6 537 733 1,099 93.6 147 264 S. aureus ATCC 29213 0.5 22.5 420 588 788 66.2 107 163 S. aureus ATCC 6538p 0.5 21.9 409 750 1,460 63.6 152 398 Mean ± SD (95% CI) for S. aureus 438 ± 67 (316-550) 666 ± 87 (501-832) 1,061 ± 296 (603-1,738) 70.6 ± 15.6 (47-102) 129 ± 24.1 (86-184) 255 ± 104 (114-507) E. faecium VA 20 2 0.203 0.94 4.14 ND b 0.14 0.62 ND E. faecium VA 21 2 0.36 1.67 33.8 ND 0.25 5.05 ND Open in a separate window a Calculations are based on total drug levels.

Techniques: